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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T72096 | Eleven-Nineteen-Leukemia Protein IN-1 | Epigenetic Reader Domain | |
Eleven-Nineteen-Leukemia Protein IN-1 is a potent inhibitor of the ENL YEATS domain, exhibiting an IC50 of 14.5 nM. It binds to the ENL protein, consequently increasing its thermal stability in vitro [1]. | |||
T72097 | Eleven-Nineteen-Leukemia Protein IN-2 | Epigenetic Reader Domain | |
Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1]. | |||
T72098 | Eleven-Nineteen-Leukemia Protein IN-3 | Epigenetic Reader Domain | |
Eleven-Nineteen-Leukemia Protein IN-3, an orally active ENL YEATS domain inhibitor, exhibits potent activity with an IC50 of 15.4 nM. It downregulates MYC expression via ENL in cells and enhances ENL protein's thermal st... |